home *** CD-ROM | disk | FTP | other *** search
| Unknown | 1992-06-06 | 311.0 KB |
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MacOS 8.1
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Win98
|
DOS
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| Confidence | Program | Detection | Match Type | Support
|
|---|
| 66%
| dexvert
| OS/2 Installation Package (archive/os2InstallPackage)
| ext
| Supported |
| 1%
| dexvert
| BeOS Installation Package (archive/beOSInstallPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Newton Package (archive/newtonPackage)
| ext
| Unsupported |
| 1%
| dexvert
| Independence War 2 mod Package (other/independenceWar2ModPackage)
| ext
| Unsupported |
| 100%
| file
| data
| default
|
|
hex view+--------+-------------------------+-------------------------+--------+--------+
|00000000| 1a 44 50 31 2e 31 00 00 | 00 00 00 00 00 05 64 00 |.DP1.1..|......d.|
|00000010| 00 00 16 00 00 00 30 30 | 00 00 00 01 9c 05 00 00 |......00|........|
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|00000380| 44 09 03 00 0a 0a 00 00 | 36 33 00 00 00 01 4e 13 |D.......|63....N.|
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|000003d0| 00 00 00 01 38 49 03 00 | 69 0b 00 00 36 39 00 00 |....8I..|i...69..|
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|00000410| 8a 0b 00 00 37 33 00 00 | 00 01 b2 88 03 00 68 0d |....73..|......h.|
|00000420| 00 00 37 34 00 00 00 01 | 1a 96 03 00 77 0c 00 00 |..74....|....w...|
|00000430| 37 35 00 00 00 01 91 a2 | 03 00 fa 0a 00 00 37 36 |75......|......76|
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|00000450| 00 01 c8 be 03 00 1e 16 | 00 00 37 38 00 00 00 01 |........|..78....|
|00000460| e6 d4 03 00 d8 0b 00 00 | 37 39 00 00 00 01 be e0 |........|79......|
|00000470| 03 00 a5 08 00 00 38 30 | 00 00 00 01 63 e9 03 00 |......80|....c...|
|00000480| 48 0f 00 00 38 31 00 00 | 00 01 ab f8 03 00 df 0b |H...81..|........|
|00000490| 00 00 38 32 00 00 00 01 | 8a 04 04 00 3f 0b 00 00 |..82....|....?...|
|000004a0| 38 33 00 00 00 01 c9 0f | 04 00 ba 0c 00 00 38 34 |83......|......84|
|000004b0| 00 00 00 01 83 1c 04 00 | d2 0d 00 00 38 35 00 00 |........|....85..|
|000004c0| 00 01 55 2a 04 00 0f 0b | 00 00 38 36 00 00 00 01 |..U*....|..86....|
|000004d0| 64 35 04 00 85 0a 00 00 | 38 37 00 00 00 01 e9 3f |d5......|87.....?|
|000004e0| 04 00 af 0c 00 00 38 38 | 00 00 00 01 98 4c 04 00 |......88|.....L..|
|000004f0| e4 09 00 00 38 39 00 00 | 00 01 7c 56 04 00 85 0d |....89..|..|V....|
|00000500| 00 00 39 30 00 00 00 01 | 01 64 04 00 34 0b 00 00 |..90....|.d..4...|
|00000510| 39 31 00 00 00 01 35 6f | 04 00 66 0d 00 00 39 32 |91....5o|..f...92|
|00000520| 00 00 00 01 9b 7c 04 00 | 58 0a 00 00 39 33 00 00 |.....|..|X...93..|
|00000530| 00 01 f3 86 04 00 2c 09 | 00 00 39 34 00 00 00 01 |......,.|..94....|
|00000540| 1f 90 04 00 f1 09 00 00 | 39 35 00 00 00 01 10 9a |........|95......|
|00000550| 04 00 a1 0d 00 00 39 36 | 00 00 00 01 b1 a7 04 00 |......96|........|
|00000560| 99 0e 00 00 39 37 00 00 | 00 01 4a b6 04 00 0e 0d |....97..|..J.....|
|00000570| 00 00 39 38 00 00 00 01 | 58 c3 04 00 ee 0b 00 00 |..98....|X.......|
|00000580| 39 39 00 00 00 01 46 cf | 04 00 d0 0c 00 00 00 00 |99....F.|........|
|00000590| 00 00 00 00 16 dc 04 00 | 00 00 00 00 24 55 6e 69 |........|....$Uni|
|000005a0| 71 75 65 5f 49 44 7b 59 | 52 42 30 39 32 30 30 7d |que_ID{Y|RB09200}|
|000005b0| 0d 0a 24 54 69 74 6c 65 | 7b 53 71 75 61 6d 6f 75 |..$Title|{Squamou|
|000005c0| 73 20 43 65 6c 6c 20 43 | 61 72 63 69 6e 6f 6d 61 |s Cell C|arcinoma|
|000005d0| 20 41 72 69 73 69 6e 67 | 20 69 6e 20 50 72 65 76 | Arising| in Prev|
|000005e0| 69 6f 75 73 6c 79 20 42 | 75 72 6e 65 64 20 6f 72 |iously B|urned or|
|000005f0| 20 49 72 72 61 64 69 61 | 74 65 64 20 53 6b 69 6e | Irradia|ted Skin|
|00000600| 7d 0d 0a 24 41 75 74 68 | 6f 72 7b 45 64 77 61 72 |}..$Auth|or{Edwar|
|00000610| 64 73 2c 20 4d 4a 0d 0a | 48 69 72 73 63 68 2c 20 |ds, MJ..|Hirsch, |
|00000620| 52 4d 0d 0a 42 72 6f 61 | 64 77 61 74 65 72 2c 20 |RM..Broa|dwater, |
|00000630| 4a 52 0d 0a 4e 65 74 73 | 63 68 65 72 2c 20 44 54 |JR..Nets|cher, DT|
|00000640| 0d 0a 41 6d 65 73 2c 20 | 46 43 7d 0d 0a 24 41 66 |..Ames, |FC}..$Af|
|00000650| 66 69 6c 69 61 74 69 6f | 6e 7b 55 6e 69 76 20 6f |filiatio|n{Univ o|
|00000660| 66 20 54 65 78 61 73 2c | 20 48 6f 75 73 74 6f 6e |f Texas,| Houston|
|00000670| 7d 0d 0a 24 4a 6f 75 72 | 6e 61 6c 7b 41 72 63 68 |}..$Jour|nal{Arch|
|00000680| 20 53 75 72 67 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b | Surg}..|$Volume{|
|00000690| 31 32 34 7d 0d 0a 24 50 | 61 67 65 7b 31 31 35 2d |124}..$P|age{115-|
|000006a0| 31 31 37 7d 0d 0a 24 44 | 61 74 65 7b 4a 61 6e 75 |117}..$D|ate{Janu|
|000006b0| 61 72 79 20 31 39 38 39 | 7d 0d 0a 24 59 42 56 6f |ary 1989|}..$YBVo|
|000006c0| 6c 7b 31 39 39 30 20 59 | 65 61 72 20 42 6f 6f 6b |l{1990 Y|ear Book|
|000006d0| 20 6f 66 20 44 65 72 6d | 61 74 6f 6c 6f 67 79 7d | of Derm|atology}|
|000006e0| 0d 0a 24 43 68 61 70 74 | 65 72 7b 31 34 2d 32 32 |..$Chapt|er{14-22|
|000006f0| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|00000700| 2e 20 53 6f 62 65 72 20 | 61 6e 64 20 46 69 74 7a |. Sober |and Fitz|
|00000710| 70 61 74 72 69 63 6b 7d | 0d 0a 24 54 61 62 6c 65 |patrick}|..$Table|
|00000720| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|00000730| 7b 4a 2e 4c 2e 20 46 65 | 77 6b 65 73 2c 20 4d 2e |{J.L. Fe|wkes, M.|
|00000740| 44 2e 7d 0d 0a 0d 0a 43 | 6f 70 79 72 69 67 68 74 |D.}....C|opyright|
|00000750| 20 28 63 29 20 59 65 61 | 72 62 6f 6f 6b 20 4d 65 | (c) Yea|rbook Me|
|00000760| 64 69 63 61 6c 20 50 75 | 62 6c 69 73 68 65 72 73 |dical Pu|blishers|
|00000770| 2c 20 49 6e 63 2e 2c 20 | 31 39 39 30 0d 0a 0d 0a |, Inc., |1990....|
|00000780| 31 39 39 30 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1990 Yea|r Book o|
|00000790| 66 20 44 65 72 6d 61 74 | 6f 6c 6f 67 79 20 28 52 |f Dermat|ology (R|
|000007a0| 29 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 31 34 2d |)....Cha|pter 14-|
|000007b0| 2d 4e 6f 6e 6d 65 6c 61 | 6e 6f 6d 61 20 53 6b 69 |-Nonmela|noma Ski|
|000007c0| 6e 20 43 61 6e 63 65 72 | 0d 0a 0d 0a 2d 2d 2d 2d |n Cancer|....----|
|000007d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000007f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000800| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000810| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 53 71 75 61 |--------|--..Squa|
|00000820| 6d 6f 75 73 20 43 65 6c | 6c 20 43 61 72 63 69 6e |mous Cel|l Carcin|
|00000830| 6f 6d 61 20 41 72 69 73 | 69 6e 67 20 69 6e 20 50 |oma Aris|ing in P|
|00000840| 72 65 76 69 6f 75 73 6c | 79 20 42 75 72 6e 65 64 |reviousl|y Burned|
|00000850| 20 6f 72 20 49 72 72 61 | 64 69 61 74 65 64 20 53 | or Irra|diated S|
|00000860| 6b 69 6e 0d 0a 0d 0a 45 | 64 77 61 72 64 73 20 4d |kin....E|dwards M|
|00000870| 4a 3b 20 48 69 72 73 63 | 68 20 52 4d 3b 20 42 72 |J; Hirsc|h RM; Br|
|00000880| 6f 61 64 77 61 74 65 72 | 20 4a 52 3b 20 4e 65 74 |oadwater| JR; Net|
|00000890| 73 63 68 65 72 20 44 54 | 3b 20 41 6d 65 73 20 46 |scher DT|; Ames F|
|000008a0| 43 0d 0a 28 55 6e 69 76 | 20 6f 66 20 54 65 78 61 |C..(Univ| of Texa|
|000008b0| 73 2c 20 48 6f 75 73 74 | 6f 6e 29 0d 0a 41 72 63 |s, Houst|on)..Arc|
|000008c0| 68 20 53 75 72 67 20 31 | 32 34 3a 31 31 35 2d 31 |h Surg 1|24:115-1|
|000008d0| 31 37 2c 20 4a 61 6e 75 | 61 72 79 20 31 39 38 39 |17, Janu|ary 1989|
|000008e0| 0d 0a 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |..------|--------|
|000008f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000920| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00000930| 0d 0a 0d 0a 41 62 73 74 | 72 61 63 74 0d 0a 0d 0a |....Abst|ract....|
|00000940| 20 20 20 20 20 53 71 75 | 61 6d 6f 75 73 20 63 65 | Squ|amous ce|
|00000950| 6c 6c 20 63 61 72 63 69 | 6e 6f 6d 61 20 28 53 43 |ll carci|noma (SC|
|00000960| 43 29 20 72 61 72 65 6c | 79 20 61 72 69 73 65 73 |C) rarel|y arises|
|00000970| 20 69 6e 20 70 72 65 76 | 69 6f 75 73 6c 79 20 69 | in prev|iously i|
|00000980| 6e 6a 75 72 65 64 20 73 | 6b 69 6e 0d 0a 28 4d 61 |njured s|kin..(Ma|
|00000990| 72 6a 6f 6c 69 6e 27 73 | 20 75 6c 63 65 72 29 2e |rjolin's| ulcer).|
|000009a0| 20 20 54 68 65 20 6e 61 | 74 75 72 61 6c 20 68 69 | The na|tural hi|
|000009b0| 73 74 6f 72 79 2c 20 70 | 61 74 74 65 72 6e 73 20 |story, p|atterns |
|000009c0| 6f 66 20 72 65 63 75 72 | 72 65 6e 63 65 2c 20 61 |of recur|rence, a|
|000009d0| 6e 64 20 73 75 72 76 69 | 76 61 6c 0d 0a 6f 66 20 |nd survi|val..of |
|000009e0| 36 36 20 70 61 74 69 65 | 6e 74 73 20 74 72 65 61 |66 patie|nts trea|
|000009f0| 74 65 64 20 66 72 6f 6d | 20 31 39 34 34 20 74 6f |ted from| 1944 to|
|00000a00| 20 31 39 38 36 20 66 6f | 72 20 53 43 43 20 61 72 | 1986 fo|r SCC ar|
|00000a10| 69 73 69 6e 67 20 66 72 | 6f 6d 20 70 72 65 76 69 |ising fr|om previ|
|00000a20| 6f 75 73 6c 79 0d 0a 62 | 75 72 6e 65 64 20 6f 72 |ously..b|urned or|
|00000a30| 20 69 72 72 61 64 69 61 | 74 65 64 20 73 6b 69 6e | irradia|ted skin|
|00000a40| 20 77 65 72 65 20 72 65 | 76 69 65 77 65 64 2e 20 | were re|viewed. |
|00000a50| 20 49 6e 6a 75 72 65 64 | 20 73 6b 69 6e 20 63 6f | Injured| skin co|
|00000a60| 6d 70 6c 69 63 61 74 65 | 64 20 62 79 20 63 68 72 |mplicate|d by chr|
|00000a70| 6f 6e 69 63 0d 0a 75 6c | 63 65 72 20 77 61 73 20 |onic..ul|cer was |
|00000a80| 65 78 70 65 63 74 65 64 | 20 74 6f 20 75 6e 64 65 |expected| to unde|
|00000a90| 72 67 6f 20 6d 61 6c 69 | 67 6e 61 6e 74 20 74 72 |rgo mali|gnant tr|
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|00000ac0| 69 65 73 0d 0a 6f 66 20 | 74 68 65 20 72 65 73 75 |ies..of |the resu|
|00000ad0| 6c 74 69 6e 67 20 63 61 | 72 63 69 6e 6f 6d 61 73 |lting ca|rcinomas|
|00000ae0| 20 77 65 72 65 20 65 78 | 70 65 63 74 65 64 20 74 | were ex|pected t|
|00000af0| 6f 20 62 65 20 73 69 6d | 69 6c 61 72 20 61 6e 64 |o be sim|ilar and|
|00000b00| 20 69 6e 64 65 70 65 6e | 64 65 6e 74 20 6f 66 20 | indepen|dent of |
|00000b10| 74 68 65 0d 0a 69 6e 69 | 74 69 61 6c 20 77 6f 75 |the..ini|tial wou|
|00000b20| 6e 64 2e 0d 0a 20 20 20 | 20 20 49 6e 69 74 69 61 |nd... | Initia|
|00000b30| 6c 20 69 6e 6a 75 72 79 | 20 68 65 61 6c 69 6e 67 |l injury| healing|
|00000b40| 20 77 61 73 20 63 6f 6d | 70 6c 69 63 61 74 65 64 | was com|plicated|
|00000b50| 20 69 6e 20 37 30 25 20 | 6f 66 20 36 36 20 70 61 | in 70% |of 66 pa|
|00000b60| 74 69 65 6e 74 73 2e 20 | 20 54 68 65 20 6d 65 61 |tients. | The mea|
|00000b70| 6e 0d 0a 69 6e 74 65 72 | 76 61 6c 20 66 72 6f 6d |n..inter|val from|
|00000b80| 20 69 6e 69 74 69 61 6c | 20 69 6e 6a 75 72 79 20 | initial| injury |
|00000b90| 74 6f 20 64 69 61 67 6e | 6f 73 69 73 20 6f 66 20 |to diagn|osis of |
|00000ba0| 53 43 43 20 77 61 73 20 | 33 37 20 79 65 61 72 73 |SCC was |37 years|
|00000bb0| 2e 20 20 4d 6f 73 74 20 | 70 61 74 69 65 6e 74 73 |. Most |patients|
|00000bc0| 0d 0a 68 61 64 20 61 20 | 63 68 72 6f 6e 69 63 20 |..had a |chronic |
|00000bd0| 69 6e 74 72 61 63 74 61 | 62 6c 65 20 75 6c 63 65 |intracta|ble ulce|
|00000be0| 72 20 69 6e 20 70 72 65 | 76 69 6f 75 73 6c 79 20 |r in pre|viously |
|00000bf0| 69 6e 6a 75 72 65 64 20 | 73 6b 69 6e 2e 20 20 52 |injured |skin. R|
|00000c00| 65 67 69 6f 6e 61 6c 20 | 72 65 6c 61 70 73 65 0d |egional |relapse.|
|00000c10| 0a 61 66 74 65 72 20 73 | 75 72 67 69 63 61 6c 20 |.after s|urgical |
|00000c20| 65 78 63 69 73 69 6f 6e | 20 6f 63 63 75 72 72 65 |excision| occurre|
|00000c30| 64 20 69 6e 20 35 38 25 | 20 6f 66 20 74 68 65 20 |d in 58%| of the |
|00000c40| 70 61 74 69 65 6e 74 73 | 2e 20 20 4f 66 20 74 68 |patients|. Of th|
|00000c50| 65 20 72 65 63 75 72 72 | 65 6e 63 65 73 2c 0d 0a |e recurr|ences,..|
|00000c60| 39 33 25 20 77 65 72 65 | 20 69 6e 20 6c 6f 63 61 |93% were| in loca|
|00000c70| 6c 20 73 6b 69 6e 20 61 | 6e 64 20 72 65 67 69 6f |l skin a|nd regio|
|00000c80| 6e 61 6c 20 6c 79 6d 70 | 68 20 6e 6f 64 65 73 2e |nal lymp|h nodes.|
|00000c90| 20 20 4f 76 65 72 61 6c | 6c 20 73 75 72 76 69 76 | Overal|l surviv|
|00000ca0| 61 6c 20 72 61 74 65 73 | 20 61 74 20 35 2c 0d 0a |al rates| at 5,..|
|00000cb0| 31 30 2c 20 61 6e 64 20 | 32 30 20 79 65 61 72 73 |10, and |20 years|
|00000cc0| 20 77 65 72 65 20 35 32 | 25 2c 20 33 34 25 2c 20 | were 52|%, 34%, |
|00000cd0| 61 6e 64 20 32 33 25 2c | 20 72 65 73 70 65 63 74 |and 23%,| respect|
|00000ce0| 69 76 65 6c 79 2e 20 20 | 54 68 65 20 35 2d 79 65 |ively. |The 5-ye|
|00000cf0| 61 72 20 73 75 72 76 69 | 76 61 6c 0d 0a 72 61 74 |ar survi|val..rat|
|00000d00| 65 73 20 61 6d 6f 6e 67 | 20 62 75 72 6e 65 64 20 |es among| burned |
|00000d10| 61 6e 64 20 69 72 72 61 | 64 69 61 74 65 64 20 70 |and irra|diated p|
|00000d20| 61 74 69 65 6e 74 73 20 | 77 65 72 65 20 63 6f 6d |atients |were com|
|00000d30| 70 61 72 61 62 6c 65 2e | 0d 0a 20 20 20 20 20 53 |parable.|.. S|
|00000d40| 71 75 61 6d 6f 75 73 20 | 63 65 6c 6c 20 63 61 72 |quamous |cell car|
|00000d50| 63 69 6e 6f 6d 61 20 61 | 72 69 73 69 6e 67 20 69 |cinoma a|rising i|
|00000d60| 6e 20 70 72 65 76 69 6f | 75 73 6c 79 20 62 75 72 |n previo|usly bur|
|00000d70| 6e 65 64 20 6f 72 20 69 | 72 72 61 64 69 61 74 65 |ned or i|rradiate|
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|00001b30| 6c 6c 79 20 77 69 74 68 | 20 61 0d 0a 68 69 67 68 |lly with| a..high|
|00001b40| 20 69 6e 64 65 78 20 6f | 66 20 73 75 73 70 69 63 | index o|f suspic|
|00001b50| 69 6f 6e 20 62 65 63 61 | 75 73 65 2c 20 74 79 70 |ion beca|use, typ|
|00001b60| 69 63 61 6c 6c 79 2c 20 | 6c 65 73 69 6f 6e 73 20 |ically, |lesions |
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|00001b80| 65 72 20 77 69 6c 6c 0d | 0a 66 6f 72 6d 2e 2d 2d |er will.|.form.--|
|00001b90| 4a 2e 4c 2e 20 46 65 77 | 6b 65 73 2c 20 4d 2e 44 |J.L. Few|kes, M.D|
|00001ba0| 2e 0d 0a 24 55 6e 69 71 | 75 65 5f 49 44 7b 59 52 |...$Uniq|ue_ID{YR|
|00001bb0| 42 30 39 32 30 32 7d 0d | 0a 24 54 69 74 6c 65 7b |B09202}.|.$Title{|
|00001bc0| 53 69 67 6e 65 74 2d 52 | 69 6e 67 20 53 71 75 61 |Signet-R|ing Squa|
|00001bd0| 6d 6f 75 73 20 43 65 6c | 6c 20 43 61 72 63 69 6e |mous Cel|l Carcin|
|00001be0| 6f 6d 61 7d 0d 0a 24 41 | 75 74 68 6f 72 7b 43 72 |oma}..$A|uthor{Cr|
|00001bf0| 61 6d 65 72 2c 20 53 46 | 0d 0a 48 65 67 67 65 6e |amer, SF|..Heggen|
|00001c00| 65 73 73 2c 20 4c 4d 7d | 0d 0a 24 41 66 66 69 6c |ess, LM}|..$Affil|
|00001c10| 69 61 74 69 6f 6e 7b 55 | 6e 69 76 20 6f 66 20 52 |iation{U|niv of R|
|00001c20| 6f 63 68 65 73 74 65 72 | 2c 20 4e 59 7d 0d 0a 24 |ochester|, NY}..$|
|00001c30| 4a 6f 75 72 6e 61 6c 7b | 41 6d 20 4a 20 43 6c 69 |Journal{|Am J Cli|
|00001c40| 6e 20 50 61 74 68 6f 6c | 7d 0d 0a 24 56 6f 6c 75 |n Pathol|}..$Volu|
|00001c50| 6d 65 7b 39 31 7d 0d 0a | 24 50 61 67 65 7b 34 38 |me{91}..|$Page{48|
|00001c60| 38 2d 34 39 31 7d 0d 0a | 24 44 61 74 65 7b 41 70 |8-491}..|$Date{Ap|
|00001c70| 72 69 6c 20 31 39 38 39 | 7d 0d 0a 24 59 42 56 6f |ril 1989|}..$YBVo|
|00001c80| 6c 7b 31 39 39 30 20 59 | 65 61 72 20 42 6f 6f 6b |l{1990 Y|ear Book|
|00001c90| 20 6f 66 20 44 65 72 6d | 61 74 6f 6c 6f 67 79 7d | of Derm|atology}|
|00001ca0| 0d 0a 24 43 68 61 70 74 | 65 72 7b 31 34 2d 32 34 |..$Chapt|er{14-24|
|00001cb0| 7d 0d 0a 24 59 42 45 64 | 69 74 6f 72 7b 44 72 73 |}..$YBEd|itor{Drs|
|00001cc0| 2e 20 53 6f 62 65 72 20 | 61 6e 64 20 46 69 74 7a |. Sober |and Fitz|
|00001cd0| 70 61 74 72 69 63 6b 7d | 0d 0a 24 54 61 62 6c 65 |patrick}|..$Table|
|00001ce0| 7b 7d 0d 0a 24 43 6f 6d | 6d 65 6e 74 61 74 6f 72 |{}..$Com|mentator|
|00001cf0| 7b 54 2e 4a 2e 20 46 6c | 6f 74 74 65 2c 20 4d 2e |{T.J. Fl|otte, M.|
|00001d00| 44 2e 7d 0d 0a 0d 0a 43 | 6f 70 79 72 69 67 68 74 |D.}....C|opyright|
|00001d10| 20 28 63 29 20 59 65 61 | 72 62 6f 6f 6b 20 4d 65 | (c) Yea|rbook Me|
|00001d20| 64 69 63 61 6c 20 50 75 | 62 6c 69 73 68 65 72 73 |dical Pu|blishers|
|00001d30| 2c 20 49 6e 63 2e 2c 20 | 31 39 39 30 0d 0a 0d 0a |, Inc., |1990....|
|00001d40| 31 39 39 30 20 59 65 61 | 72 20 42 6f 6f 6b 20 6f |1990 Yea|r Book o|
|00001d50| 66 20 44 65 72 6d 61 74 | 6f 6c 6f 67 79 20 28 52 |f Dermat|ology (R|
|00001d60| 29 0d 0a 0d 0a 43 68 61 | 70 74 65 72 20 31 34 2d |)....Cha|pter 14-|
|00001d70| 2d 4e 6f 6e 6d 65 6c 61 | 6e 6f 6d 61 20 53 6b 69 |-Nonmela|noma Ski|
|00001d80| 6e 20 43 61 6e 63 65 72 | 0d 0a 0d 0a 2d 2d 2d 2d |n Cancer|....----|
|00001d90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001da0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001db0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001dc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001dd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 0d 0a 53 69 67 6e |--------|--..Sign|
|00001de0| 65 74 2d 52 69 6e 67 20 | 53 71 75 61 6d 6f 75 73 |et-Ring |Squamous|
|00001df0| 20 43 65 6c 6c 20 43 61 | 72 63 69 6e 6f 6d 61 0d | Cell Ca|rcinoma.|
|00001e00| 0a 0d 0a 43 72 61 6d 65 | 72 20 53 46 3b 20 48 65 |...Crame|r SF; He|
|00001e10| 67 67 65 6e 65 73 73 20 | 4c 4d 0d 0a 28 55 6e 69 |ggeness |LM..(Uni|
|00001e20| 76 20 6f 66 20 52 6f 63 | 68 65 73 74 65 72 2c 20 |v of Roc|hester, |
|00001e30| 4e 59 29 0d 0a 41 6d 20 | 4a 20 43 6c 69 6e 20 50 |NY)..Am |J Clin P|
|00001e40| 61 74 68 6f 6c 20 39 31 | 3a 34 38 38 2d 34 39 31 |athol 91|:488-491|
|00001e50| 2c 20 41 70 72 69 6c 20 | 31 39 38 39 0d 0a 2d 2d |, April |1989..--|
|00001e60| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001e70| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001e80| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001e90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00001ea0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 0d 0a 0d 0a |--------|----....|
|00001eb0| 41 62 73 74 72 61 63 74 | 0d 0a 0d 0a 20 20 20 20 |Abstract|.... |
|00001ec0| 20 53 69 67 6e 65 74 20 | 72 69 6e 67 20 66 65 61 | Signet |ring fea|
|00001ed0| 74 75 72 65 73 20 68 61 | 76 65 20 62 65 65 6e 20 |tures ha|ve been |
|00001ee0| 63 6f 6e 73 69 64 65 72 | 65 64 20 70 61 74 68 6f |consider|ed patho|
|00001ef0| 67 6e 6f 6d 6f 6e 69 63 | 20 6f 66 0d 0a 61 64 65 |gnomonic| of..ade|
|00001f00| 6e 6f 63 61 72 63 69 6e | 6f 6d 61 2e 20 20 41 20 |nocarcin|oma. A |
|00001f10| 70 61 74 69 65 6e 74 20 | 77 69 74 68 20 61 20 70 |patient |with a p|
|00001f20| 6f 6f 72 6c 79 20 64 69 | 66 66 65 72 65 6e 74 69 |oorly di|fferenti|
|00001f30| 61 74 65 64 20 63 75 74 | 61 6e 65 6f 75 73 20 73 |ated cut|aneous s|
|00001f40| 71 75 61 6d 6f 75 73 0d | 0a 63 65 6c 6c 20 63 61 |quamous.|.cell ca|
|00001f50| 72 63 69 6e 6f 6d 61 20 | 68 61 64 20 61 20 6d 6f |rcinoma |had a mo|
|00001f60| 6e 6f 64 69 73 70 65 72 | 73 65 64 2c 20 69 6e 76 |nodisper|sed, inv|
|00001f70| 61 73 69 76 65 20 73 69 | 67 6e 65 74 20 72 69 6e |asive si|gnet rin|
|00001f80| 67 20 63 6f 6d 70 6f 6e | 65 6e 74 2e 0d 0a 0d 0a |g compon|ent.....|
|00001f90| 20 20 20 20 20 4d 61 6e | 2c 20 36 39 2c 20 68 61 | Man|, 69, ha|
|00001fa0| 64 20 61 20 66 6f 72 65 | 68 65 61 64 20 6c 65 73 |d a fore|head les|
|00001fb0| 69 6f 6e 20 74 68 6f 75 | 67 68 74 20 74 6f 20 62 |ion thou|ght to b|
|00001fc0| 65 20 61 20 6b 65 72 61 | 74 6f 61 63 61 6e 74 68 |e a kera|toacanth|
|00001fd0| 6f 6d 61 2e 20 20 41 20 | 79 65 61 72 0d 0a 6c 61 |oma. A |year..la|
|00001fe0| 74 65 72 2c 20 61 6e 20 | 75 6c 63 65 72 61 74 65 |ter, an |ulcerate|
|00001ff0| 64 20 6e 6f 64 75 6c 65 | 20 63 6c 61 73 73 65 64 |d nodule| classed|
|00002000| 20 61 73 20 61 20 77 65 | 6c 6c 2d 64 69 66 66 65 | as a we|ll-diffe|
|00002010| 72 65 6e 74 69 61 74 65 | 64 20 73 71 75 61 6d 6f |rentiate|d squamo|
|00002020| 75 73 20 63 65 6c 6c 0d | 0a 63 61 72 63 69 6e 6f |us cell.|.carcino|
|00002030| 6d 61 20 61 72 6f 73 65 | 20 69 6e 20 61 73 73 6f |ma arose| in asso|
|00002040| 63 69 61 74 69 6f 6e 20 | 77 69 74 68 20 61 63 74 |ciation |with act|
|00002050| 69 6e 69 63 20 6b 65 72 | 61 74 6f 73 69 73 2e 20 |inic ker|atosis. |
|00002060| 20 53 6b 65 6c 65 74 61 | 6c 20 6d 75 73 63 6c 65 | Skeleta|l muscle|
|00002070| 20 77 61 73 0d 0a 69 6e | 76 6f 6c 76 65 64 2e 20 | was..in|volved. |
|00002080| 20 54 68 69 72 74 65 65 | 6e 20 6f 70 65 72 61 74 | Thirtee|n operat|
|00002090| 69 6f 6e 73 20 77 65 72 | 65 20 64 6f 6e 65 20 69 |ions wer|e done i|
|000020a0| 6e 20 74 68 65 20 6e 65 | 78 74 20 35 20 79 65 61 |n the ne|xt 5 yea|
|000020b0| 72 73 20 66 6f 72 20 6d | 75 6c 74 69 70 6c 65 0d |rs for m|ultiple.|
|000020c0| 0a 72 65 63 75 72 72 65 | 6e 74 20 73 71 75 61 6d |.recurre|nt squam|
|000020d0| 6f 75 73 20 63 65 6c 6c | 20 63 61 6e 63 65 72 73 |ous cell| cancers|
|000020e0| 20 6f 66 20 74 68 65 20 | 66 6f 72 65 68 65 61 64 | of the |forehead|
|000020f0| 20 61 6e 64 20 63 6f 6e | 74 69 67 75 6f 75 73 20 | and con|tiguous |
|00002100| 73 63 61 6c 70 3b 20 74 | 68 65 72 65 0d 0a 77 65 |scalp; t|here..we|
|00002110| 72 65 20 61 74 20 6c 65 | 61 73 74 20 34 20 73 65 |re at le|ast 4 se|
|00002120| 70 61 72 61 74 65 20 70 | 72 69 6d 61 72 79 20 74 |parate p|rimary t|
|00002130| 75 6d 6f 72 73 2e 20 20 | 54 75 6d 6f 72 20 63 65 |umors. |Tumor ce|
|00002140| 6c 6c 73 20 63 6f 6e 74 | 69 6e 75 65 64 20 74 6f |lls cont|inued to|
|00002150| 20 63 6f 6e 74 61 69 6e | 0d 0a 6c 61 72 67 65 20 | contain|..large |
|00002160| 61 6d 6f 75 6e 74 73 20 | 6f 66 20 65 6f 73 69 6e |amounts |of eosin|
|00002170| 6f 70 68 69 6c 69 63 20 | 63 79 74 6f 70 6c 61 73 |ophilic |cytoplas|
|00002180| 6d 3b 20 61 20 63 6c 65 | 61 72 2d 63 65 6c 6c 20 |m; a cle|ar-cell |
|00002190| 63 6f 6d 70 6f 6e 65 6e | 74 20 77 61 73 20 6e 6f |componen|t was no|
|000021a0| 74 65 64 0d 0a 6f 63 63 | 61 73 69 6f 6e 61 6c 6c |ted..occ|asionall|
|000021b0| 79 2e 20 20 41 6e 20 69 | 6e 76 61 73 69 76 65 20 |y. An i|nvasive |
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|000021d0| 69 6e 6f 6d 61 20 63 6f | 6d 70 6f 6e 65 6e 74 20 |inoma co|mponent |
|000021e0| 77 61 73 20 66 6f 75 6e | 64 20 35 20 79 65 61 72 |was foun|d 5 year|
|000021f0| 73 0d 0a 61 66 74 65 72 | 20 74 68 65 20 66 69 72 |s..after| the fir|
|00002200| 73 74 20 65 78 61 6d 69 | 6e 61 74 69 6f 6e 2e 20 |st exami|nation. |
|00002210| 20 54 68 65 20 63 65 6c | 6c 73 20 77 65 72 65 20 | The cel|ls were |
|00002220| 6e 65 67 61 74 69 76 65 | 20 66 6f 72 20 6d 75 63 |negative| for muc|
|00002230| 69 6e 20 62 79 20 74 68 | 65 0d 0a 4b 72 65 79 62 |in by th|e..Kreyb|
|00002240| 65 72 67 20 73 74 61 69 | 6e 2c 20 62 75 74 20 73 |erg stai|n, but s|
|00002250| 6f 6d 65 20 63 6f 6e 74 | 61 69 6e 65 64 20 66 6c |ome cont|ained fl|
|00002260| 6f 63 63 75 6c 65 6e 74 | 2c 20 70 65 72 69 6f 64 |occulent|, period|
|00002270| 69 63 20 61 63 69 64 2d | 53 63 68 69 66 66 2d 70 |ic acid-|Schiff-p|
|00002280| 6f 73 69 74 69 76 65 2c | 0d 0a 64 69 61 73 74 61 |ositive,|..diasta|
|00002290| 73 65 2d 73 65 6e 73 69 | 74 69 76 65 20 6d 61 74 |se-sensi|tive mat|
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|000022b0| 61 6c 20 73 69 67 6e 65 | 74 20 72 69 6e 67 20 63 |al signe|t ring c|
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|000022d0| 6f 6e 0d 0a 72 65 76 69 | 65 77 69 6e 67 20 70 61 |on..revi|ewing pa|
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|000022f0| 6d 6d 75 6e 6f 73 74 61 | 69 6e 69 6e 67 20 6f 66 |mmunosta|ining of|
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|00002320| 73 74 72 6f 6e 67 20 66 | 6f 72 20 6b 65 72 61 74 |strong f|or kerat|
|00002330| 69 6e 20 69 6e 20 63 6f | 6e 63 65 6e 74 72 69 63 |in in co|ncentric|
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|00002360| 65 6c 6c 73 2e 20 20 41 | 20 6e 6f 64 65 0d 0a 61 |ells. A| node..a|
|00002370| 73 70 69 72 61 74 65 20 | 63 6f 6e 74 61 69 6e 65 |spirate |containe|
|00002380| 64 20 6d 65 74 61 73 74 | 61 74 69 63 20 73 71 75 |d metast|atic squ|
|00002390| 61 6d 6f 75 73 20 63 65 | 6c 6c 20 63 61 72 63 69 |amous ce|ll carci|
|000023a0| 6e 6f 6d 61 2c 20 69 6e | 63 6c 75 64 69 6e 67 20 |noma, in|cluding |
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|000023c0| 20 63 6f 6d 70 6f 6e 65 | 6e 74 2e 20 20 54 68 65 | compone|nt. The|
|000023d0| 20 74 75 6d 6f 72 20 70 | 72 6f 76 65 64 20 72 61 | tumor p|roved ra|
|000023e0| 64 69 6f 72 65 73 69 73 | 74 61 6e 74 20 61 6e 64 |dioresis|tant and|
|000023f0| 20 6c 6f 63 61 6c 6c 79 | 20 61 67 67 72 65 73 73 | locally| aggress|
|00002400| 69 76 65 2e 20 20 54 68 | 65 0d 0a 70 61 74 69 65 |ive. Th|e..patie|
|00002410| 6e 74 20 62 65 63 61 6d | 65 20 68 79 70 65 72 63 |nt becam|e hyperc|
|00002420| 61 6c 63 65 6d 69 63 20 | 61 6e 64 20 73 65 70 74 |alcemic |and sept|
|00002430| 69 63 20 61 6e 64 20 64 | 69 65 64 20 36 20 79 65 |ic and d|ied 6 ye|
|00002440| 61 72 73 20 61 66 74 65 | 72 20 70 72 65 73 65 6e |ars afte|r presen|
|00002450| 74 61 74 69 6f 6e 2e 0d | 0a 0d 0a 20 20 20 20 20 |tation..|... |
|00002460| 54 68 69 73 20 69 73 20 | 74 68 65 20 66 69 72 73 |This is |the firs|
|00002470| 74 20 6b 6e 6f 77 6e 20 | 72 65 70 6f 72 74 20 6f |t known |report o|
|00002480| 66 20 73 69 67 6e 65 74 | 20 72 69 6e 67 20 73 71 |f signet| ring sq|
|00002490| 75 61 6d 6f 75 73 20 63 | 65 6c 6c 20 63 61 72 63 |uamous c|ell carc|
|000024a0| 69 6e 6f 6d 61 2e 0d 0a | 54 68 65 20 63 61 72 63 |inoma...|The carc|
|000024b0| 69 6e 6f 6d 61 20 61 72 | 6f 73 65 20 69 6e 20 61 |inoma ar|ose in a|
|000024c0| 20 66 69 65 6c 64 20 6f | 66 20 61 63 74 69 6e 69 | field o|f actini|
|000024d0| 63 20 6b 65 72 61 74 6f | 73 69 73 20 62 75 74 20 |c kerato|sis but |
|000024e0| 6c 65 64 20 74 6f 20 74 | 68 65 20 70 61 74 69 65 |led to t|he patie|
|000024f0| 6e 74 27 73 0d 0a 64 65 | 61 74 68 2e 20 20 54 68 |nt's..de|ath. Th|
|00002500| 69 73 20 63 61 73 65 20 | 6d 61 79 20 62 65 20 61 |is case |may be a|
|00002510| 6e 20 65 78 61 6d 70 6c | 65 20 6f 66 20 67 72 65 |n exampl|e of gre|
|00002520| 61 74 65 72 20 61 62 65 | 72 72 61 74 69 6f 6e 73 |ater abe|rrations|
|00002530| 20 66 72 6f 6d 20 6e 6f | 72 6d 61 6c 0d 0a 64 69 | from no|rmal..di|
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|00002580| 68 65 72 65 66 6f 72 65 | 0d 0a 6d 6f 72 65 20 61 |herefore|..more a|
|00002590| 67 67 72 65 73 73 69 76 | 65 20 6e 65 6f 70 6c 61 |ggressiv|e neopla|
|000025a0| 73 6d 73 2e 0d 0a 0d 0a | 50 6f 73 74 2d 43 6f 6d |sms.....|Post-Com|
|000025b0| 6d 65 6e 74 0d 0a 0d 0a | 20 20 20 20 20 54 68 69 |ment....| Thi|
|000025c0| 73 20 69 73 20 31 20 6f | 66 20 32 20 70 61 70 65 |s is 1 o|f 2 pape|
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|000025f0| 65 74 20 63 65 6c 6c 20 | 74 75 6d 6f 72 73 2e 20 |et cell |tumors. |
|00002600| 20 54 68 69 73 0d 0a 73 | 71 75 61 6d 6f 75 73 20 | This..s|quamous |
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|00002620| 76 65 72 79 20 72 61 72 | 65 20 76 61 72 69 61 6e |very rar|e varian|
|00002630| 74 2e 20 20 54 68 65 20 | 64 69 66 66 65 72 65 6e |t. The |differen|
|00002640| 74 69 61 6c 20 64 69 61 | 67 6e 6f 73 69 73 0d 0a |tial dia|gnosis..|
|00002650| 69 6e 63 6c 75 64 65 73 | 20 61 20 76 61 72 69 65 |includes| a varie|
|00002660| 74 79 20 6f 66 20 74 75 | 6d 6f 72 73 3b 20 68 6f |ty of tu|mors; ho|
|00002670| 77 65 76 65 72 2c 20 64 | 69 61 67 6e 6f 73 74 69 |wever, d|iagnosti|
|00002680| 63 20 66 65 61 74 75 72 | 65 73 20 6f 66 20 73 71 |c featur|es of sq|
|00002690| 75 61 6d 6f 75 73 0d 0a | 63 61 72 63 69 6e 6f 6d |uamous..|carcinom|
|000026a0| 61 20 61 72 65 20 73 74 | 69 6c 6c 20 70 72 65 73 |a are st|ill pres|
|000026b0| 65 6e 74 2e 2d 2d 54 2e | 4a 2e 20 46 6c 6f 74 74 |ent.--T.|J. Flott|
|000026c0| 65 2c 20 4d 2e 44 2e 0d | 0a 24 55 6e 69 71 75 65 |e, M.D..|.$Unique|
|000026d0| 5f 49 44 7b 59 52 42 30 | 39 32 30 33 7d 0d 0a 24 |_ID{YRB0|9203}..$|
|000026e0| 54 69 74 6c 65 7b 53 69 | 67 6e 65 74 20 52 69 6e |Title{Si|gnet Rin|
|000026f0| 67 20 43 65 6c 6c 20 4c | 79 6d 70 68 6f 6d 61 20 |g Cell L|ymphoma |
|00002700| 6f 66 20 54 20 43 65 6c | 6c 20 54 79 70 65 7d 0d |of T Cel|l Type}.|
|00002710| 0a 24 41 75 74 68 6f 72 | 7b 43 72 6f 73 73 2c 20 |.$Author|{Cross, |
|00002720| 50 41 0d 0a 45 79 64 65 | 6e 2c 20 42 50 0d 0a 48 |PA..Eyde|n, BP..H|
|00002730| 61 72 72 69 73 2c 20 4d | 7d 0d 0a 24 41 66 66 69 |arris, M|}..$Affi|
|00002740| 6c 69 61 74 69 6f 6e 7b | 43 68 72 69 73 74 69 65 |liation{|Christie|
|00002750| 20 48 6f 73 70 3b 20 48 | 6f 6c 74 20 52 61 64 69 | Hosp; H|olt Radi|
|00002760| 75 6d 20 49 6e 73 74 2c | 20 4d 61 6e 63 68 65 73 |um Inst,| Manches|
|00002770| 74 65 72 2c 20 45 6e 67 | 6c 61 6e 64 7d 0d 0a 24 |ter, Eng|land}..$|
|00002780| 4a 6f 75 72 6e 61 6c 7b | 4a 20 43 6c 69 6e 20 50 |Journal{|J Clin P|
|00002790| 61 74 68 6f 6c 7d 0d 0a | 24 56 6f 6c 75 6d 65 7b |athol}..|$Volume{|
|000027a0| 34 32 7d 0d 0a 24 50 61 | 67 65 7b 32 33 39 2d 32 |42}..$Pa|ge{239-2|
|000027b0| 34 35 7d 0d 0a 24 44 61 | 74 65 7b 31 39 38 39 7d |45}..$Da|te{1989}|
|000027c0| 0d 0a 24 59 42 56 6f 6c | 7b 31 39 39 30 20 59 65 |..$YBVol|{1990 Ye|
|000027d0| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 44 65 72 6d 61 |ar Book |of Derma|
|000027e0| 74 6f 6c 6f 67 79 7d 0d | 0a 24 43 68 61 70 74 65 |tology}.|.$Chapte|
|000027f0| 72 7b 31 34 2d 32 35 7d | 0d 0a 24 59 42 45 64 69 |r{14-25}|..$YBEdi|
|00002800| 74 6f 72 7b 44 72 73 2e | 20 53 6f 62 65 72 20 61 |tor{Drs.| Sober a|
|00002810| 6e 64 20 46 69 74 7a 70 | 61 74 72 69 63 6b 7d 0d |nd Fitzp|atrick}.|
|00002820| 0a 24 54 61 62 6c 65 7b | 7d 0d 0a 24 43 6f 6d 6d |.$Table{|}..$Comm|
|00002830| 65 6e 74 61 74 6f 72 7b | 54 2e 4a 2e 20 46 6c 6f |entator{|T.J. Flo|
|00002840| 74 74 65 2c 20 4d 2e 44 | 2e 7d 0d 0a 0d 0a 43 6f |tte, M.D|.}....Co|
|00002850| 70 79 72 69 67 68 74 20 | 28 63 29 20 59 65 61 72 |pyright |(c) Year|
|00002860| 62 6f 6f 6b 20 4d 65 64 | 69 63 61 6c 20 50 75 62 |book Med|ical Pub|
|00002870| 6c 69 73 68 65 72 73 2c | 20 49 6e 63 2e 2c 20 31 |lishers,| Inc., 1|
|00002880| 39 39 30 0d 0a 0d 0a 31 | 39 39 30 20 59 65 61 72 |990....1|990 Year|
|00002890| 20 42 6f 6f 6b 20 6f 66 | 20 44 65 72 6d 61 74 6f | Book of| Dermato|
|000028a0| 6c 6f 67 79 20 28 52 29 | 0d 0a 0d 0a 43 68 61 70 |logy (R)|....Chap|
|000028b0| 74 65 72 20 31 34 2d 2d | 4e 6f 6e 6d 65 6c 61 6e |ter 14--|Nonmelan|
|000028c0| 6f 6d 61 20 53 6b 69 6e | 20 43 61 6e 63 65 72 0d |oma Skin| Cancer.|
|000028d0| 0a 0d 0a 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |...-----|--------|
|000028e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000028f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002900| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002910| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002920| 2d 0d 0a 53 69 67 6e 65 | 74 20 52 69 6e 67 20 43 |-..Signe|t Ring C|
|00002930| 65 6c 6c 20 4c 79 6d 70 | 68 6f 6d 61 20 6f 66 20 |ell Lymp|homa of |
|00002940| 54 20 43 65 6c 6c 20 54 | 79 70 65 0d 0a 0d 0a 43 |T Cell T|ype....C|
|00002950| 72 6f 73 73 20 50 41 3b | 20 45 79 64 65 6e 20 42 |ross PA;| Eyden B|
|00002960| 50 3b 20 48 61 72 72 69 | 73 20 4d 0d 0a 28 43 68 |P; Harri|s M..(Ch|
|00002970| 72 69 73 74 69 65 20 48 | 6f 73 70 3b 20 48 6f 6c |ristie H|osp; Hol|
|00002980| 74 20 52 61 64 69 75 6d | 20 49 6e 73 74 2c 20 4d |t Radium| Inst, M|
|00002990| 61 6e 63 68 65 73 74 65 | 72 2c 20 45 6e 67 6c 61 |ancheste|r, Engla|
|000029a0| 6e 64 29 0d 0a 4a 20 43 | 6c 69 6e 20 50 61 74 68 |nd)..J C|lin Path|
|000029b0| 6f 6c 20 34 32 3a 32 33 | 39 2d 32 34 35 2c 20 31 |ol 42:23|9-245, 1|
|000029c0| 39 38 39 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |989..---|--------|
|000029d0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029e0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|000029f0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002a00| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00002a10| 2d 2d 2d 0d 0a 0d 0a 41 | 62 73 74 72 61 63 74 0d |---....A|bstract.|
|00002a20| 0a 0d 0a 20 20 20 20 20 | 53 69 67 6e 65 74 20 72 |... |Signet r|
|00002a30| 69 6e 67 20 6c 79 6d 70 | 68 6f 6d 61 20 69 73 20 |ing lymp|homa is |
|00002a40| 61 20 72 61 72 65 20 68 | 69 73 74 6f 6c 6f 67 69 |a rare h|istologi|
|00002a50| 63 20 76 61 72 69 61 6e | 74 20 6f 66 20 6e 6f 6e |c varian|t of non|
|00002a60| 2d 48 6f 64 67 6b 69 6e | 27 73 0d 0a 6c 79 6d 70 |-Hodgkin|'s..lymp|
|00002a70| 68 6f 6d 61 2e 20 20 54 | 68 65 20 63 6c 65 61 72 |homa. T|he clear|
|00002a80| 20 76 61 63 75 6f 6c 65 | 20 74 79 70 65 20 6f 66 | vacuole| type of|
|00002a90| 20 73 69 67 6e 65 74 20 | 72 69 6e 67 20 61 70 70 | signet |ring app|
|00002aa0| 65 61 72 61 6e 63 65 20 | 69 73 20 72 61 72 65 20 |earance |is rare |
|00002ab0| 69 6e 20 54 20 63 65 6c | 6c 0d 0a 6c 79 6d 70 68 |in T cel|l..lymph|
|00002ac0| 6f 6d 61 2e 0d 0a 0d 0a | 20 20 20 20 20 4d 61 6e |oma.....| Man|
|00002ad0| 2c 20 37 35 2c 20 77 69 | 74 68 20 61 20 31 2d 79 |, 75, wi|th a 1-y|
|00002ae0| 65 61 72 20 68 69 73 74 | 6f 72 79 20 6f 66 20 61 |ear hist|ory of a|
|00002af0| 20 70 61 69 6e 6c 65 73 | 73 2c 20 73 6c 6f 77 2d | painles|s, slow-|
|00002b00| 67 72 6f 77 69 6e 67 20 | 70 69 6d 70 6c 65 20 6f |growing |pimple o|
|00002b10| 6e 20 68 69 73 0d 0a 63 | 68 69 6e 2c 20 77 61 73 |n his..c|hin, was|
|00002b20| 20 6f 74 68 65 72 77 69 | 73 65 20 69 6e 20 67 6f | otherwi|se in go|
|00002b30| 6f 64 20 67 65 6e 65 72 | 61 6c 20 68 65 61 6c 74 |od gener|al healt|
|00002b40| 68 2e 20 20 41 20 62 69 | 6f 70 73 79 20 77 61 73 |h. A bi|opsy was|
|00002b50| 20 64 6f 6e 65 20 6f 6e | 20 32 20 70 61 6c 65 2c | done on| 2 pale,|
|00002b60| 20 66 69 72 6d 0d 0a 6c | 65 73 69 6f 6e 73 20 30 | firm..l|esions 0|
|00002b70| 2e 37 20 63 6d 20 69 6e | 20 64 69 61 6d 65 74 65 |.7 cm in| diamete|
|00002b80| 72 20 6f 6e 20 74 68 65 | 20 6c 65 66 74 20 73 69 |r on the| left si|
|00002b90| 64 65 20 6f 66 20 74 68 | 65 20 63 68 69 6e 3b 20 |de of th|e chin; |
|00002ba0| 6c 61 74 65 72 2c 20 61 | 20 73 6d 61 6c 6c 65 72 |later, a| smaller|
|00002bb0| 20 70 69 6e 6b 0d 0a 70 | 61 70 69 6c 6c 6f 6d 61 | pink..p|apilloma|
|00002bc0| 74 6f 75 73 20 6c 65 73 | 69 6f 6e 20 6d 65 64 69 |tous les|ion medi|
|00002bd0| 61 6c 20 74 6f 20 74 68 | 65 20 70 72 65 76 69 6f |al to th|e previo|
|00002be0| 75 73 20 62 69 6f 70 73 | 79 20 73 63 61 72 20 77 |us biops|y scar w|
|00002bf0| 61 73 20 6e 6f 74 65 64 | 2e 20 20 54 68 65 20 63 |as noted|. The c|
|00002c00| 68 69 6e 0d 0a 6e 6f 64 | 75 6c 65 20 67 72 65 77 |hin..nod|ule grew|
|00002c10| 20 73 6f 6d 65 77 68 61 | 74 20 69 6e 20 74 68 65 | somewha|t in the|
|00002c20| 20 6e 65 78 74 20 33 20 | 6d 6f 6e 74 68 73 20 61 | next 3 |months a|
|00002c30| 6e 64 20 77 61 73 20 66 | 75 72 74 68 65 72 20 65 |nd was f|urther e|
|00002c40| 78 63 69 73 65 64 2e 20 | 20 54 68 65 0d 0a 70 61 |xcised. | The..pa|
|00002c50| 74 69 65 6e 74 20 77 61 | 73 20 77 65 6c 6c 20 31 |tient wa|s well 1|
|00002c60| 35 20 6d 6f 6e 74 68 73 | 20 61 66 74 65 72 20 74 |5 months| after t|
|00002c70| 68 65 20 66 69 72 73 74 | 20 65 78 61 6d 69 6e 61 |he first| examina|
|00002c80| 74 69 6f 6e 2e 20 20 4d | 6f 73 74 20 63 65 6c 6c |tion. M|ost cell|
|00002c90| 73 20 77 65 72 65 0d 0a | 6d 65 64 69 75 6d 20 74 |s were..|medium t|
|00002ca0| 6f 20 6c 61 72 67 65 2c | 20 77 69 74 68 20 72 6f |o large,| with ro|
|00002cb0| 75 6e 64 20 6f 72 20 62 | 65 61 6e 2d 73 68 61 70 |und or b|ean-shap|
|00002cc0| 65 64 20 6e 75 63 6c 65 | 69 20 68 61 76 69 6e 67 |ed nucle|i having|
|00002cd0| 20 66 69 6e 65 6c 79 20 | 67 72 61 6e 75 6c 61 72 | finely |granular|
|00002ce0| 0d 0a 63 68 72 6f 6d 61 | 74 69 6e 2e 20 20 53 6d |..chroma|tin. Sm|
|00002cf0| 61 6c 6c 65 72 20 63 65 | 6c 6c 73 20 77 69 74 68 |aller ce|lls with|
|00002d00| 20 68 79 70 65 72 63 68 | 72 6f 6d 61 74 69 63 20 | hyperch|romatic |
|00002d10| 6e 75 63 6c 65 69 20 61 | 6e 64 20 73 63 61 74 74 |nuclei a|nd scatt|
|00002d20| 65 72 65 64 20 63 65 6c | 6c 73 20 77 69 74 68 0d |ered cel|ls with.|
|00002d30| 0a 61 20 73 69 6e 67 6c | 65 20 63 6c 65 61 72 20 |.a singl|e clear |
|00002d40| 63 79 74 6f 70 6c 61 73 | 6d 69 63 20 76 61 63 75 |cytoplas|mic vacu|
|00002d50| 6f 6c 65 20 61 6c 73 6f | 20 77 65 72 65 20 70 72 |ole also| were pr|
|00002d60| 65 73 65 6e 74 2e 20 20 | 54 68 65 20 73 69 67 6e |esent. |The sign|
|00002d70| 65 74 20 72 69 6e 67 20 | 63 65 6c 6c 73 0d 0a 63 |et ring |cells..c|
|00002d80| 6f 6d 70 72 69 73 65 64 | 20 31 35 25 20 74 6f 20 |omprised| 15% to |
|00002d90| 32 30 25 20 6f 66 20 63 | 65 6c 6c 73 20 69 6e 20 |20% of c|ells in |
|00002da0| 74 68 65 20 73 65 63 6f | 6e 64 20 62 69 6f 70 73 |the seco|nd biops|
|00002db0| 79 20 73 70 65 63 69 6d | 65 6e 2e 20 20 56 61 73 |y specim|en. Vas|
|00002dc0| 63 75 6c 61 72 0d 0a 70 | 72 6f 6c 69 66 65 72 61 |cular..p|rolifera|
|00002dd0| 74 69 6f 6e 20 77 61 73 | 20 6d 6f 64 65 72 61 74 |tion was| moderat|
|00002de0| 65 64 2e 20 20 54 68 65 | 20 74 75 6d 6f 72 20 63 |ed. The| tumor c|
|00002df0| 65 6c 6c 73 20 73 74 61 | 69 6e 65 64 20 76 61 72 |ells sta|ined var|
|00002e00| 69 61 62 6c 79 20 66 6f | 72 20 54 20 63 65 6c 6c |iably fo|r T cell|
|00002e10| 0d 0a 6d 61 72 6b 65 72 | 73 20 61 6e 64 20 77 65 |..marker|s and we|
|00002e20| 72 65 20 75 6e 69 66 6f | 72 6d 6c 79 20 6e 65 67 |re unifo|rmly neg|
|00002e30| 61 74 69 76 65 20 66 6f | 72 20 42 20 63 65 6c 6c |ative fo|r B cell|
|00002e40| 20 6d 61 72 6b 65 72 73 | 2e 0d 0a 0d 0a 20 20 20 | markers|..... |
|00002e50| 20 20 42 65 63 61 75 73 | 65 20 74 68 65 20 75 6c | Becaus|e the ul|
|00002e60| 74 72 61 73 74 72 75 63 | 74 75 72 61 6c 20 61 70 |trastruc|tural ap|
|00002e70| 70 65 61 72 61 6e 63 65 | 20 6f 66 20 74 68 65 20 |pearance| of the |
|00002e80| 73 69 67 6e 65 74 20 72 | 69 6e 67 20 76 61 63 75 |signet r|ing vacu|
|00002e90| 6f 6c 65 73 20 77 61 73 | 0d 0a 69 64 65 6e 74 69 |oles was|..identi|
|00002ea0| 63 61 6c 20 74 6f 20 74 | 68 61 74 20 6f 66 20 74 |cal to t|hat of t|
|00002eb0| 68 65 20 6d 6f 72 65 20 | 63 6f 6d 6d 6f 6e 20 42 |he more |common B|
|00002ec0| 20 63 65 6c 6c 20 73 69 | 67 6e 65 74 20 72 69 6e | cell si|gnet rin|
|00002ed0| 67 20 6c 79 6d 70 68 6f | 6d 61 20 6f 66 20 74 68 |g lympho|ma of th|
|00002ee0| 65 20 63 6c 65 61 72 0d | 0a 76 61 63 75 6f 6c 65 |e clear.|.vacuole|
|00002ef0| 20 74 79 70 65 2c 20 74 | 68 65 20 76 61 63 75 6f | type, t|he vacuo|
|00002f00| 6c 65 73 20 70 72 65 73 | 75 6d 61 62 6c 79 20 61 |les pres|umably a|
|00002f10| 72 65 20 64 65 72 69 76 | 65 64 20 66 72 6f 6d 20 |re deriv|ed from |
|00002f20| 6d 75 6c 74 69 76 65 73 | 69 63 75 6c 61 72 20 62 |multives|icular b|
|00002f30| 6f 64 69 65 73 2e 0d 0a | 41 6c 6c 20 34 20 70 61 |odies...|All 4 pa|
|00002f40| 74 69 65 6e 74 73 20 65 | 6e 63 6f 75 6e 74 65 72 |tients e|ncounter|
|00002f50| 65 64 20 74 6f 20 64 61 | 74 65 20 77 69 74 68 20 |ed to da|te with |
|00002f60| 54 20 63 65 6c 6c 20 73 | 69 67 6e 65 74 20 72 69 |T cell s|ignet ri|
|00002f70| 6e 67 20 6c 79 6d 70 68 | 6f 6d 61 20 77 65 72 65 |ng lymph|oma were|
|00002f80| 20 66 69 72 73 74 0d 0a | 73 65 65 6e 20 66 6f 72 | first..|seen for|
|00002f90| 20 63 75 74 61 6e 65 6f | 75 73 20 64 69 73 65 61 | cutaneo|us disea|
|00002fa0| 73 65 2e 20 20 54 68 65 | 20 70 72 6f 67 6e 6f 73 |se. The| prognos|
|00002fb0| 69 73 20 6d 61 79 20 62 | 65 20 67 6f 6f 64 3b 20 |is may b|e good; |
|00002fc0| 74 68 65 20 33 20 70 72 | 65 76 69 6f 75 73 0d 0a |the 3 pr|evious..|
|00002fd0| 70 61 74 69 65 6e 74 73 | 20 72 65 73 70 6f 6e 64 |patients| respond|
|00002fe0| 65 64 20 74 6f 20 72 61 | 64 69 6f 74 68 65 72 61 |ed to ra|diothera|
|00002ff0| 70 79 20 61 6e 64 20 63 | 6f 6d 62 69 6e 61 74 69 |py and c|ombinati|
|00003000| 6f 6e 20 63 68 65 6d 6f | 74 68 65 72 61 70 79 20 |on chemo|therapy |
|00003010| 64 65 73 70 69 74 65 20 | 6e 6f 64 61 6c 0d 0a 61 |despite |nodal..a|
|00003020| 6e 64 20 65 76 65 6e 20 | 77 69 64 65 73 70 72 65 |nd even |widespre|
|00003030| 61 64 20 64 69 73 65 61 | 73 65 2e 0d 0a 0d 0a 50 |ad disea|se.....P|
|00003040| 6f 73 74 2d 43 6f 6d 6d | 65 6e 74 0d 0a 0d 0a 20 |ost-Comm|ent.... |
|00003050| 20 20 20 20 54 68 69 73 | 20 70 61 70 65 72 20 64 | This| paper d|
|00003060| 65 73 63 72 69 62 65 73 | 20 61 6e 20 75 6e 75 73 |escribes| an unus|
|00003070| 75 61 6c 20 73 69 67 6e | 65 74 20 63 65 6c 6c 20 |ual sign|et cell |
|00003080| 74 75 6d 6f 72 20 74 68 | 61 74 20 77 61 73 20 61 |tumor th|at was a|
|00003090| 20 76 61 72 69 61 6e 74 | 20 6f 66 0d 0a 6e 6f 6e | variant| of..non|
|000030a0| 2d 48 6f 64 67 6b 69 6e | 27 73 20 6c 79 6d 70 68 |-Hodgkin|'s lymph|
|000030b0| 6f 6d 61 2c 20 69 6c 6c | 75 73 74 72 61 74 69 6e |oma, ill|ustratin|
|000030c0| 67 20 74 68 65 20 6c 69 | 67 68 74 20 61 6e 64 20 |g the li|ght and |
|000030d0| 65 6c 65 63 74 72 6f 6e | 20 6d 69 63 72 6f 73 63 |electron| microsc|
|000030e0| 6f 70 69 63 0d 0a 66 69 | 6e 64 69 6e 67 73 2e 20 |opic..fi|ndings. |
|000030f0| 20 54 68 65 20 64 69 66 | 66 65 72 65 6e 74 69 61 | The dif|ferentia|
|00003100| 6c 20 64 69 61 67 6e 6f | 73 69 73 20 69 6e 63 6c |l diagno|sis incl|
|00003110| 75 64 65 73 20 61 20 76 | 61 72 69 65 74 79 20 6f |udes a v|ariety o|
|00003120| 66 20 74 75 6d 6f 72 73 | 20 69 6e 63 6c 75 64 69 |f tumors| includi|
|00003130| 6e 67 0d 0a 73 69 67 6e | 65 74 20 63 65 6c 6c 20 |ng..sign|et cell |
|00003140| 63 61 72 63 69 6e 6f 6d | 61 20 28 73 65 65 20 41 |carcinom|a (see A|
|00003150| 62 73 74 72 61 63 74 20 | 31 34 2d 32 34 29 2e 2d |bstract |14-24).-|
|00003160| 2d 54 2e 4a 2e 20 46 6c | 6f 74 74 65 2c 20 4d 2e |-T.J. Fl|otte, M.|
|00003170| 44 2e 0d 0a 24 55 6e 69 | 71 75 65 5f 49 44 7b 59 |D...$Uni|que_ID{Y|
|00003180| 52 42 30 39 32 30 34 7d | 0d 0a 24 54 69 74 6c 65 |RB09204}|..$Title|
|00003190| 7b 43 75 74 61 6e 65 6f | 75 73 20 4c 79 6d 70 68 |{Cutaneo|us Lymph|
|000031a0| 6f 69 64 20 48 79 70 65 | 72 70 6c 61 73 69 61 3a |oid Hype|rplasia:|
|000031b0| 20 20 49 6d 6d 75 6e 6f | 6c 6f 67 69 63 20 43 68 | Immuno|logic Ch|
|000031c0| 61 72 61 63 74 65 72 69 | 73 74 69 63 73 20 61 6e |aracteri|stics an|
|000031d0| 64 20 41 73 73 65 73 73 | 6d 65 6e 74 20 6f 66 20 |d Assess|ment of |
|000031e0| 43 72 69 74 65 72 69 61 | 20 52 65 63 65 6e 74 6c |Criteria| Recentl|
|000031f0| 79 20 50 72 6f 70 6f 73 | 65 64 20 61 73 20 44 69 |y Propos|ed as Di|
|00003200| 61 67 6e 6f 73 74 69 63 | 20 6f 66 20 4d 61 6c 69 |agnostic| of Mali|
|00003210| 67 6e 61 6e 74 20 4c 79 | 6d 70 68 6f 6d 61 7d 0d |gnant Ly|mphoma}.|
|00003220| 0a 24 41 75 74 68 6f 72 | 7b 4d 65 64 65 69 72 6f |.$Author|{Medeiro|
|00003230| 73 2c 20 4c 4a 0d 0a 50 | 69 63 6b 65 72 2c 20 4c |s, LJ..P|icker, L|
|00003240| 4a 0d 0a 41 62 65 6c 2c | 20 45 41 0d 0a 48 75 2c |J..Abel,| EA..Hu,|
|00003250| 20 43 2d 48 0d 0a 48 6f | 70 70 65 2c 20 52 54 0d | C-H..Ho|ppe, RT.|
|00003260| 0a 57 61 72 6e 6b 65 2c | 20 52 41 0d 0a 57 6f 6f |.Warnke,| RA..Woo|
|00003270| 64 2c 20 47 53 7d 0d 0a | 24 41 66 66 69 6c 69 61 |d, GS}..|$Affilia|
|00003280| 74 69 6f 6e 7b 53 74 61 | 6e 66 6f 72 64 20 55 6e |tion{Sta|nford Un|
|00003290| 69 76 3b 20 56 41 20 4d | 65 64 20 43 74 72 2c 20 |iv; VA M|ed Ctr, |
|000032a0| 50 61 6c 6f 20 41 6c 74 | 6f 2c 20 43 61 6c 69 66 |Palo Alt|o, Calif|
|000032b0| 7d 0d 0a 24 4a 6f 75 72 | 6e 61 6c 7b 4a 20 41 6d |}..$Jour|nal{J Am|
|000032c0| 20 41 63 61 64 20 44 65 | 72 6d 61 74 6f 6c 7d 0d | Acad De|rmatol}.|
|000032d0| 0a 24 56 6f 6c 75 6d 65 | 7b 32 31 7d 0d 0a 24 50 |.$Volume|{21}..$P|
|000032e0| 61 67 65 7b 39 32 39 2d | 39 34 32 7d 0d 0a 24 44 |age{929-|942}..$D|
|000032f0| 61 74 65 7b 4e 6f 76 65 | 6d 62 65 72 20 31 39 38 |ate{Nove|mber 198|
|00003300| 39 7d 0d 0a 24 59 42 56 | 6f 6c 7b 31 39 39 30 20 |9}..$YBV|ol{1990 |
|00003310| 59 65 61 72 20 42 6f 6f | 6b 20 6f 66 20 44 65 72 |Year Boo|k of Der|
|00003320| 6d 61 74 6f 6c 6f 67 79 | 7d 0d 0a 24 43 68 61 70 |matology|}..$Chap|
|00003330| 74 65 72 7b 31 34 2d 32 | 36 7d 0d 0a 24 59 42 45 |ter{14-2|6}..$YBE|
|00003340| 64 69 74 6f 72 7b 44 72 | 73 2e 20 53 6f 62 65 72 |ditor{Dr|s. Sober|
|00003350| 20 61 6e 64 20 46 69 74 | 7a 70 61 74 72 69 63 6b | and Fit|zpatrick|
|00003360| 7d 0d 0a 24 54 61 62 6c | 65 7b 7d 0d 0a 24 43 6f |}..$Tabl|e{}..$Co|
|00003370| 6d 6d 65 6e 74 61 74 6f | 72 7b 54 2e 4a 2e 20 46 |mmentato|r{T.J. F|
|00003380| 6c 6f 74 74 65 2c 20 4d | 2e 44 2e 7d 0d 0a 0d 0a |lotte, M|.D.}....|
|00003390| 43 6f 70 79 72 69 67 68 | 74 20 28 63 29 20 59 65 |Copyrigh|t (c) Ye|
|000033a0| 61 72 62 6f 6f 6b 20 4d | 65 64 69 63 61 6c 20 50 |arbook M|edical P|
|000033b0| 75 62 6c 69 73 68 65 72 | 73 2c 20 49 6e 63 2e 2c |ublisher|s, Inc.,|
|000033c0| 20 31 39 39 30 0d 0a 0d | 0a 31 39 39 30 20 59 65 | 1990...|.1990 Ye|
|000033d0| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 44 65 72 6d 61 |ar Book |of Derma|
|000033e0| 74 6f 6c 6f 67 79 20 28 | 52 29 0d 0a 0d 0a 43 68 |tology (|R)....Ch|
|000033f0| 61 70 74 65 72 20 31 34 | 2d 2d 4e 6f 6e 6d 65 6c |apter 14|--Nonmel|
|00003400| 61 6e 6f 6d 61 20 53 6b | 69 6e 20 43 61 6e 63 65 |anoma Sk|in Cance|
|00003410| 72 0d 0a 0d 0a 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |r....---|--------|
|00003420| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003430| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003440| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003450| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00003460| 2d 2d 2d 0d 0a 43 75 74 | 61 6e 65 6f 75 73 20 4c |---..Cut|aneous L|
|00003470| 79 6d 70 68 6f 69 64 20 | 48 79 70 65 72 70 6c 61 |ymphoid |Hyperpla|
|00003480| 73 69 61 3a 20 20 49 6d | 6d 75 6e 6f 6c 6f 67 69 |sia: Im|munologi|
|00003490| 63 20 43 68 61 72 61 63 | 74 65 72 69 73 74 69 63 |c Charac|teristic|
|000034a0| 73 20 61 6e 64 20 41 73 | 73 65 73 73 6d 65 6e 74 |s and As|sessment|
|000034b0| 20 6f 66 0d 0a 43 72 69 | 74 65 72 69 61 20 52 65 | of..Cri|teria Re|
|000034c0| 63 65 6e 74 6c 79 20 50 | 72 6f 70 6f 73 65 64 20 |cently P|roposed |
|000034d0| 61 73 20 44 69 61 67 6e | 6f 73 74 69 63 20 6f 66 |as Diagn|ostic of|
|000034e0| 20 4d 61 6c 69 67 6e 61 | 6e 74 20 4c 79 6d 70 68 | Maligna|nt Lymph|
|000034f0| 6f 6d 61 0d 0a 0d 0a 4d | 65 64 65 69 72 6f 73 20 |oma....M|edeiros |
|00003500| 4c 4a 3b 20 50 69 63 6b | 65 72 20 4c 4a 3b 20 41 |LJ; Pick|er LJ; A|
|00003510| 62 65 6c 20 45 41 3b 20 | 48 75 20 43 2d 48 3b 20 |bel EA; |Hu C-H; |
|00003520| 48 6f 70 70 65 20 52 54 | 3b 20 57 61 72 6e 6b 65 |Hoppe RT|; Warnke|
|00003530| 20 52 41 3b 20 57 6f 6f | 64 20 47 53 0d 0a 28 53 | RA; Woo|d GS..(S|
|00003540| 74 61 6e 66 6f 72 64 20 | 55 6e 69 76 3b 20 56 41 |tanford |Univ; VA|
|00003550| 20 4d 65 64 20 43 74 72 | 2c 20 50 61 6c 6f 20 41 | Med Ctr|, Palo A|
|00003560| 6c 74 6f 2c 20 43 61 6c | 69 66 29 0d 0a 4a 20 41 |lto, Cal|if)..J A|
|00003570| 6d 20 41 63 61 64 20 44 | 65 72 6d 61 74 6f 6c 20 |m Acad D|ermatol |
|00003580| 32 31 3a 39 32 39 2d 39 | 34 32 2c 20 4e 6f 76 65 |21:929-9|42, Nove|
|00003590| 6d 62 65 72 20 31 39 38 | 39 0d 0a 2d 2d 2d 2d 2d |mber 198|9..-----|
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|00003ee0| 6f 6e 73 2e 2d 2d 54 2e | 4a 2e 0d 0a 46 6c 6f 74 |ons.--T.|J...Flot|
|00003ef0| 74 65 2c 20 4d 2e 44 2e | 0d 0a 24 55 6e 69 71 75 |te, M.D.|..$Uniqu|
|00003f00| 65 5f 49 44 7b 59 52 42 | 30 39 32 30 35 7d 0d 0a |e_ID{YRB|09205}..|
|00003f10| 24 54 69 74 6c 65 7b 46 | 6f 6c 6c 69 63 75 6c 61 |$Title{F|ollicula|
|00003f20| 72 20 4d 75 63 69 6e 6f | 73 69 73 3a 20 20 43 6c |r Mucino|sis: Cl|
|00003f30| 69 6e 69 63 61 6c 20 61 | 6e 64 20 48 69 73 74 6f |inical a|nd Histo|
|00003f40| 70 61 74 68 6f 6c 6f 67 | 69 63 20 53 74 75 64 79 |patholog|ic Study|
|00003f50| 7d 0d 0a 24 41 75 74 68 | 6f 72 7b 47 69 62 73 6f |}..$Auth|or{Gibso|
|00003f60| 6e 2c 20 4c 45 0d 0a 4d | 75 6c 6c 65 72 2c 20 53 |n, LE..M|uller, S|
|00003f70| 41 0d 0a 4c 65 69 66 65 | 72 6d 61 6e 2c 20 4b 4d |A..Leife|rman, KM|
|00003f80| 0d 0a 50 65 74 65 72 73 | 2c 20 4d 53 7d 0d 0a 24 |..Peters|, MS}..$|
|00003f90| 41 66 66 69 6c 69 61 74 | 69 6f 6e 7b 4d 61 79 6f |Affiliat|ion{Mayo|
|00003fa0| 20 43 6c 69 6e 63 20 61 | 6e 64 20 46 6f 75 6e 64 | Clinc a|nd Found|
|00003fb0| 2c 20 52 6f 63 68 65 73 | 74 65 72 2c 20 4d 69 6e |, Roches|ter, Min|
|00003fc0| 6e 7d 0d 0a 24 4a 6f 75 | 72 6e 61 6c 7b 4a 20 41 |n}..$Jou|rnal{J A|
|00003fd0| 6d 20 41 63 61 64 20 44 | 65 72 6d 61 74 6f 6c 7d |m Acad D|ermatol}|
|00003fe0| 0d 0a 24 56 6f 6c 75 6d | 65 7b 32 30 7d 0d 0a 24 |..$Volum|e{20}..$|
|00003ff0| 50 61 67 65 7b 34 34 31 | 2d 34 34 36 7d 0d 0a 24 |Page{441|-446}..$|
|00004000| 44 61 74 65 7b 4d 61 72 | 63 68 20 31 39 38 39 7d |Date{Mar|ch 1989}|
|00004010| 0d 0a 24 59 42 56 6f 6c | 7b 31 39 39 30 20 59 65 |..$YBVol|{1990 Ye|
|00004020| 61 72 20 42 6f 6f 6b 20 | 6f 66 20 44 65 72 6d 61 |ar Book |of Derma|
|00004030| 74 6f 6c 6f 67 79 7d 0d | 0a 24 43 68 61 70 74 65 |tology}.|.$Chapte|
|00004040| 72 7b 31 34 2d 32 37 7d | 0d 0a 24 59 42 45 64 69 |r{14-27}|..$YBEdi|
|00004050| 74 6f 72 7b 44 72 73 2e | 20 53 6f 62 65 72 20 61 |tor{Drs.| Sober a|
|00004060| 6e 64 20 46 69 74 7a 70 | 61 74 72 69 63 6b 7d 0d |nd Fitzp|atrick}.|
|00004070| 0a 24 54 61 62 6c 65 7b | 54 61 62 6c 65 20 4f 6d |.$Table{|Table Om|
|00004080| 69 74 74 65 64 7d 0d 0a | 24 43 6f 6d 6d 65 6e 74 |itted}..|$Comment|
|00004090| 61 74 6f 72 7b 54 2e 4a | 2e 20 46 6c 6f 74 74 65 |ator{T.J|. Flotte|
|000040a0| 2c 20 4d 2e 44 2e 7d 0d | 0a 0d 0a 43 6f 70 79 72 |, M.D.}.|...Copyr|
|000040b0| 69 67 68 74 20 28 63 29 | 20 59 65 61 72 62 6f 6f |ight (c)| Yearboo|
|000040c0| 6b 20 4d 65 64 69 63 61 | 6c 20 50 75 62 6c 69 73 |k Medica|l Publis|
|000040d0| 68 65 72 73 2c 20 49 6e | 63 2e 2c 20 31 39 39 30 |hers, In|c., 1990|
|000040e0| 0d 0a 0d 0a 31 39 39 30 | 20 59 65 61 72 20 42 6f |....1990| Year Bo|
|000040f0| 6f 6b 20 6f 66 20 44 65 | 72 6d 61 74 6f 6c 6f 67 |ok of De|rmatolog|
|00004100| 79 20 28 52 29 0d 0a 0d | 0a 43 68 61 70 74 65 72 |y (R)...|.Chapter|
|00004110| 20 31 34 2d 2d 4e 6f 6e | 6d 65 6c 61 6e 6f 6d 61 | 14--Non|melanoma|
|00004120| 20 53 6b 69 6e 20 43 61 | 6e 63 65 72 0d 0a 0d 0a | Skin Ca|ncer....|
|00004130| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004140| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004150| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004160| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004170| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 0d 0a |--------|------..|
|00004180| 46 6f 6c 6c 69 63 75 6c | 61 72 20 4d 75 63 69 6e |Follicul|ar Mucin|
|00004190| 6f 73 69 73 3a 20 20 43 | 6c 69 6e 69 63 61 6c 20 |osis: C|linical |
|000041a0| 61 6e 64 20 48 69 73 74 | 6f 70 61 74 68 6f 6c 6f |and Hist|opatholo|
|000041b0| 67 69 63 20 53 74 75 64 | 79 0d 0a 0d 0a 47 69 62 |gic Stud|y....Gib|
|000041c0| 73 6f 6e 20 4c 45 3b 20 | 4d 75 6c 6c 65 72 20 53 |son LE; |Muller S|
|000041d0| 41 3b 20 4c 65 69 66 65 | 72 6d 61 6e 20 4b 4d 3b |A; Leife|rman KM;|
|000041e0| 20 50 65 74 65 72 73 20 | 4d 53 0d 0a 28 4d 61 79 | Peters |MS..(May|
|000041f0| 6f 20 43 6c 69 6e 63 20 | 61 6e 64 20 46 6f 75 6e |o Clinc |and Foun|
|00004200| 64 2c 20 52 6f 63 68 65 | 73 74 65 72 2c 20 4d 69 |d, Roche|ster, Mi|
|00004210| 6e 6e 29 0d 0a 4a 20 41 | 6d 20 41 63 61 64 20 44 |nn)..J A|m Acad D|
|00004220| 65 72 6d 61 74 6f 6c 20 | 32 30 3a 34 34 31 2d 34 |ermatol |20:441-4|
|00004230| 34 36 2c 20 4d 61 72 63 | 68 20 31 39 38 39 0d 0a |46, Marc|h 1989..|
|00004240| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004250| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004260| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004270| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004280| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 0d 0a |--------|------..|
|00004290| 0d 0a 41 62 73 74 72 61 | 63 74 0d 0a 0d 0a 20 20 |..Abstra|ct.... |
|000042a0| 20 20 20 46 6f 6c 6c 69 | 63 75 6c 61 72 20 6d 75 | Folli|cular mu|
|000042b0| 63 69 6e 6f 73 69 73 20 | 68 61 73 20 61 20 63 6f |cinosis |has a co|
|000042c0| 6d 6d 6f 6e 20 68 69 73 | 74 6f 70 61 74 68 6f 6c |mmon his|topathol|
|000042d0| 6f 67 69 63 20 70 61 74 | 74 65 72 6e 20 6f 66 20 |ogic pat|tern of |
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|00004430| 20 20 41 6e 20 61 64 64 | 69 74 69 6f 6e 61 6c 20 | An add|itional |
|00004440| 32 32 20 73 6b 69 6e 20 | 62 69 6f 70 73 79 20 73 |22 skin |biopsy s|
|00004450| 70 65 63 69 6d 65 6e 73 | 20 66 72 6f 6d 20 31 35 |pecimens| from 15|
|00004460| 0d 0a 70 61 74 69 65 6e | 74 73 20 77 69 74 68 20 |..patien|ts with |
|00004470| 6d 79 63 6f 73 69 73 20 | 66 75 6e 67 6f 69 64 65 |mycosis |fungoide|
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|000044a0| 66 6f 6c 6c 6f 77 2d 75 | 70 20 77 61 73 20 31 30 |follow-u|p was 10|
|000044b0| 0d 0a 79 65 61 72 73 2e | 0d 0a 20 20 20 20 20 4f |..years.|.. O|
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|00004500| 0a 66 6f 6c 6c 69 63 75 | 6c 61 72 20 6d 75 63 69 |.follicu|lar muci|
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|00004580| 6c 6c 69 63 75 6c 61 72 | 20 6d 75 63 69 6e 6f 73 |llicular| mucinos|
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|00004620| 28 46 69 67 20 31 34 2d | 32 29 20 72 65 76 65 61 |(Fig 14-|2) revea|
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|000046a0| 20 20 20 20 20 4e 6f 20 | 73 69 6e 67 6c 65 20 63 | No |single c|
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|000047d0| 0a 0d 0a 20 20 20 20 20 | 54 68 69 73 20 70 61 70 |... |This pap|
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|00004840| 6f 74 20 62 65 20 61 73 | 73 6f 63 69 61 74 65 64 |ot be as|sociated|
|00004850| 20 77 69 74 68 20 6c 79 | 6d 70 68 6f 6d 61 73 2e | with ly|mphomas.|
|00004860| 20 20 48 6f 77 65 76 65 | 72 2c 0d 0a 74 68 61 74 | Howeve|r,..that|
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|000048c0| 20 43 61 72 65 66 75 6c | 20 65 76 61 6c 75 61 74 | Careful| evaluat|
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|00004b60| 0a 43 68 61 70 74 65 72 | 20 31 34 2d 2d 4e 6f 6e |.Chapter| 14--Non|
|00004b70| 6d 65 6c 61 6e 6f 6d 61 | 20 53 6b 69 6e 20 43 61 |melanoma| Skin Ca|
|00004b80| 6e 63 65 72 0d 0a 0d 0a | 2d 2d 2d 2d 2d 2d 2d 2d |ncer....|--------|
|00004b90| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004ba0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004bb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004bc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004bd0| 2d 2d 2d 2d 2d 2d 0d 0a | 50 61 72 61 70 73 6f 72 |------..|Parapsor|
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|00004c20| 65 6e 63 65 2c 0d 0a 31 | 39 37 30 20 74 6f 20 31 |ence,..1|970 to 1|
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|00004c80| 61 64 20 44 65 72 6d 61 | 74 6f 6c 20 32 31 3a 39 |ad Derma|tol 21:9|
|00004c90| 31 39 2d 39 32 33 2c 20 | 4e 6f 76 65 6d 62 65 72 |19-923, |November|
|00004ca0| 20 31 39 38 39 0d 0a 2d | 2d 2d 2d 2d 2d 2d 2d 2d | 1989..-|--------|
|00004cb0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004cc0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004cd0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004ce0| 2d 2d 2d 2d 2d 2d 2d 2d | 2d 2d 2d 2d 2d 2d 2d 2d |--------|--------|
|00004cf0| 2d 2d 2d 2d 2d 0d 0a 0d | 0a 41 62 73 74 72 61 63 |-----...|.Abstrac|
|00004d00| 74 0d 0a 0d 0a 20 20 20 | 20 20 41 74 74 65 6d 70 |t.... | Attemp|
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|00004d30| 61 72 61 70 73 6f 72 69 | 61 73 69 73 20 69 6e 74 |arapsori|asis int|
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|00004ec0| 70 73 79 20 73 70 65 63 | 69 6d 65 6e 73 0d 0a 66 |psy spec|imens..f|
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|00004f30| 69 73 20 66 75 6e 67 6f | 69 64 65 73 20 77 65 72 |is fungo|ides wer|
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|00004f90| 0d 0a 20 20 20 20 20 4d | 79 63 6f 73 69 73 20 66 |.. M|ycosis f|
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|00004fc0| 20 70 61 74 69 65 6e 74 | 73 20 77 69 74 68 20 70 | patient|s with p|
|00004fd0| 61 72 61 70 73 6f 72 69 | 61 73 69 73 2e 0d 0a 4f |arapsori|asis...O|
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|00005010| 6f 72 6b 65 64 20 69 6e | 20 69 6e 64 75 73 74 72 |orked in| industr|
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